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Novartis believes that HTA should be guided by 12 key principles: (1) HTAs should be based on a clear, sophisticated and differentiated view of what constitutes value (2) HTAs should be transparent and balanced (3) HTAs should be based on early and inclusive dialogue, including with patients (4) evaluations should allow new data to be considered (5) flexibility is required in handling uncertainty (6) comprehensive understanding of the benefits of a medicine in disease management is needed (7) payers should commit to rewarding added value (8) HTA outcomes should be implemented (9) HTA should apply to all healthcare interventions, not just medicines (10) appraisal should take place at the national level (11) HTA should remain separate from regulatory review and (12) evaluations should take into account all benefits, direct as well as indirect..
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